At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.janssenrnd.com/ for more information. We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.janssenrnd.com/ for more information.
We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
We are looking for a skilled and motivated computational chemist for the position of PhD Student, at our Antwerp, Belgium site. The position is part of the EU Horizon2020 project ALLODD, an Innovative Trainings Network (ITN) in the Marie Skłodowska-Curie Actions program.
The ALLODD project is a collaboration between 13 academic and industrial organizations with 14 PhD students in total. The aim of ALLODD is to train a new generation of scientists to exploit the concept of allostery in drug design, putting together a whole array of technologies to identify and characterize allosteric modulators of protein function that will be applied to therapeutically relevant systems.
You will assess how well structure-based methods can identify ligandable allosteric sites and how well ligands for these sites can be identified. For this you will use several conformational sampling methods to identify allosteric sites in disease relevant protein targets. You will apply virtual screening using docking, pharmacophore-based, and AI methods to see if known allosteric ligands can be identified. In addition, you will apply the developed approach prospectively to targets of interest and select compounds for purchase or for synthesis. These compounds will then be tested for activity.
Your primary location will be at Janssen in Belgium, and the program foresees two 2-month secondments at other academic partner locations.
Responsibilities of the PhD student will include:
Qualifications
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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